arthritis rheumatol 2019 71 suppl 10

Cardiovascular disease rotated-square. Authors Atul Deodhar 1 , Denis Poddubnyy 2 , Cesar Pacheco-Tena 3 , Carlo Salvarani 4 , Eric Lespessailles 5 , â¦ Arthritis Rheumatol. Arthritis Rheumatol. Arthritis & Rheumatology published by Wiley Periodicals, Inc. on behalf of American College of Rheumatology. Arthritis Rheumatol 2019;71 (Suppl. Treating axial spondyloarthritis and peripheral spondyloarthritis, especially psoriatic arthritis, to target: 2017 update of recommendations by an international task force . Med. Li LY, Lu N, Lacaille D, Xie H, Esdaile J, Avina-Zubieta JA. Arthritis Rheumatol. 2017;37(6): 955–961. [5]van Vollenhoven, et al . Grinnell-Merrick LL, Lydon EJ, Mixon AM, Saalfeld W. Rheumatol Ther. 9. Arthritis Rheumatol. COVID-19 is an emerging, rapidly evolving situation. 2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis. JAK inhibitors rotated-square. In this phase III randomized, double-blind, placebo-controlled trial, adult patients with an inadequate response to or intolerance of 1 or 2 TNFi and an established diagnosis of axial SpA (according to the Assessment of SpondyloArthritis international Society [ASAS] criteria for radiographic axial SpA, with radiographic sacroiliitis defined according to the modified New York criteria and ≥1 feature of SpA) were recruited and randomized 1:1:1 to receive placebo or 80-mg subcutaneous ixekizumab every 2 weeks (IXEQ2W) or 4 weeks (IXEQ4W), with an 80-mg or 160-mg starting dose. Arthritis Rheumatol. We recruited rheumatologists nationally to participate in moderated structured group teleconference discussions using the nominal group technique. Rheumatol. JAK inhibitors rotated-square. Details are given according to the Consolidated Standards of…, Proportion of patients achieving A , 40% improvement in disease activity according to…, Major secondary outcomes investigating disease…, Major secondary outcomes investigating disease activity, function, and quality of life among patients…, Spondyloarthritis Research Consortium of Canada…, Spondyloarthritis Research Consortium of Canada ( SPARCC ) magnetic resonance imaging ( MRI…, NLM Epub 2020 Sep 15. Related topics. SOURCES: Jones J et al. Amigues I, Tugcu A, Russo C, Giles JT, Morgenstein R, Zartoshti A, et al. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Filgotinib rotated-square. The safety profile of secukinumab through Wk 52 was consistent with previous reports.3-4 References: [1]McInnes IB, et al. One death was reported (IXEQ2W group). 2019;71(10):1599-1613. Research on the effect of psoriatic arthritis (PsA) on bone mineral density (BMD) is inconsistent. 2019;71(suppl 10). Â© 2019, American College of Rheumatology. UCB. Prevalence of axial spondylarthritis in the United States: estimates from a cross‐sectional survey. 2017 Oct;69 Suppl 10:1-4426. doi: 10.1002/art.40321. Approximately 10 days after getting your blood drawn, you can directly access your Vectra test report online by going to VectraScore.com and clicking on the myVectra™ link. Missing Disclaimer Information in the TitleâPage Footnotes of the Article by Rims et al (Arthritis Rheumatol, April 2019) Pages: 907 First Published: 27 May 2019 Arthritis Rheumatol. To investigate the efficacy and safety of ixekizumab in patients with active radiographic axial spondyloarthritis (SpA) and prior inadequate response to or intolerance of 1 or 2 tumor necrosis factor inhibitors (TNFi). 2016; 68 (suppl 10) Smolen JS, Schöls M, Braun J, et al. 6:214. doi: 10.3389/fmed.2019.00214. Kvien T, Glennås A, Knudsrød O, Smedstad L. The validity of self-reported diagnosis of rheumatoid arthritis: results from a population survey followed by clinical examinations. The incidence of PsA is ∼6 per 100,000 per year, and the prevalence is ∼1–2 per 1,000 in the general population. Arthritis Rheumatol. oral and genital ulcers, erythema nodosum and papulopustular lesions), arthritis and uveitis, it can also affect the vessels, nervous system and gastrointestinal tract. 2019:1-13. Epub 2019 Aug 28. Clipboard, Search History, and several other advanced features are temporarily unavailable. This site needs JavaScript to work properly. 2019;71(Suppl 10):1894. Safety profile of baricitinib for the treatment of rheumatoid arthritis up to 7 years: an updated integrated safety analysis. 2019; 71 (suppl 10). Background/Purpose: Olokizumab (OKZ) is a new humanized monoclonal antibody targeting IL-6 1, 2. Risk of venous thromboembolism in rheumatoid arthritis patients initiating biologic and non-biologic DMARDs, a population-based study. Results: Impact of Ixekizumab on Work Productivity in Patients with Ankylosing Spondylitis: Results from the COAST-V and COAST-W Trials at 52 Weeks. 2016 Oct;68 Suppl 10:1-4550. doi: 10.1002/art.39977. 2019;71 (suppl 10). 2019; 71 (suppl 10). Here we present the results of the first phase III study of OKZ in patients with Rheumatoid Arthritis â¦ Arthritis Rheumatol. [Google Scholar] ... with computed tomography-based tool for the evaluation of joint counts and disease activity in patients with rheumatoid arthritis. UL1 TR000371/TR/NCATS NIH HHS/United States, Reveille JD, Witter JP, Weisman MH. Arthritis Rheumatol. Presented at: 2019 ACR/ARP Annual Meeting; November 8-13, 2019â¦ Secondary outcomes and safety were also assessed. Furst D, Wan G, Liu J, Zhu J, Bartels-Peculis L, Panaccio M, Fleischmann R. Improved Patient-Reported Outcomes in Patients with Persistently Active Rheumatoid Arthritis Following Treatment with Repository Corticotropin Injection [abstract]. 2 Data on File, Mallinckrodt, 2019. | Ixekizumab treatment for 16 weeks in patients with active radiographic axial SpA and previous inadequate response to or intolerance of 1 or 2 TNFi yields rapid and significant improvements in the signs and symptoms of radiographic axial SpA versus placebo. 2019 Oct;71(10):1285-1299. doi: 10.1002/acr.24025. Please enable it to take advantage of the complete set of features! Although classical clinical manifestations are mucocutaneous lesions (i.e. 2019;71(suppl 10 Arthritis Rheumatol. Related content Robinson PC, Sengupta R, Siebert S. Non-radiographic axial spondyloarthritis (nr-axSpA): advances in classification, imaging and therapy. Disposition of the patients. Methods: In a rheumatic disease population (51.4% RA, 23.8% axial SpA, and 19.6% PsA), patients reported that their disease had moderate to severe effects on their quality of life (51.9%), work/daily activities (49.2%), emotional well-being (41.0%), personal relationships (26.0%), and close relatives’ lives (32.3%). Previous Issue | Next Issue. 2019;71(9):1472-82. View this table: Table. Epub 2019 Mar 8. Inflammatory bowel disease and anterior uveitis in patients treated with ixekizumab for radiographic axial spondyloarthritis: results from two phase 3 studies through 52 weeks. GO TO SECTION. Ixekizumab, an interleukin-17A antagonist in the treatment of ankylosing spondylitis or radiographic axial spondyloarthritis in patients previously untreated with biological disease-modifying anti-rheumatic drugs (COAST-V): 16 week results of a phase 3 randomised, double-blind, active-controlled and placebo-controlled trial. Treatment strategies in axial spondyloarthritis: what, when and how? Efficacy, Safety, and Pharmacodynamic Effects of the Brutonâs Tyrosine Kinase Inhibitor, Fenebrutinib (GDC-0853), in Moderate to Severe Systemic Lupus Erythematosus: Results of a Phase 2 Randomized Controlled Trial [abstract]. Trial registration: Arthritis & Rheumatology, an official journal of the American College of Rheumatology, is a peer-reviewed publication for scientists and clinicians interested in the natural history, pathophysiology, â¦ Lancet 2019;393:2303-11. A Multicenter Randomized Study in Early Rheumatoid Arthritis to Compare Active Conventional Therapy versus Three Biological Treatments: 24 Week Efficacy and Safety Results of the NORD-STAR Trial ... Kim Hørslev-Petersen 8, Till Uhlig 9, Gerdur Grondal 10, Mikkel Østergaard 11, Marte Heiberg 2, Jos Twisk 12, ... Arthritis Rheumatol. Arthritis Rheumatol 2018;70(Suppl 10). Arthritis Rheumatol. Arthritis Rheumatol. Presented at: 2019 ACR/ARP Annual Meeting; November 8-13, 2019â¦ COVID-19 is an emerging, rapidly evolving situation. 2019;71(suppl 10). Efuni E, Cytryn S, Boland P, Sandigursky S. Risk of immunotherapy related toxicity in patients with rheumatoid arthritis [abstract 1339]. Behcet’s syndrome (BS) is a variable vessel vasculitis that often follows a relapsing and remitting course. Lancet 2007;369:1379–90. 2020;72(suppl 10). Efficacy and safety of romilkimab in diffuse cutaneous systemic sclerosis (dcSSc): a randomized, double-blind, placebo-controlled, 24-week, proof of concept study [abstract]. Google Scholar 2014;371:326–38. Citation: Zhang J-R, Pang D-D and Dai S-M (2019) Non-steroidal Anti-inflammatory Drugs Are Unlikely to Inhibit Radiographic Progression of Ankylosing Spondylitis: A Systematic Review. Arthritis Rheumatol. Arthritis Rheumatol. Epub 2012 Feb 2. Castellanos-Moreira R et al. Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X): a randomised, placebo-controlled trial. Arthritis Rheumatol. 2020 Dec;7(4):759-774. doi: 10.1007/s40744-020-00225-4. Arthritis Rheumatol. 2019;71(suppl 10): Abstract 847. 2015 Jul 17;(7):CD010952. Arthritis Rheumatol. doi: 10.1093/rheumatology/keaa435. ACR/ARP 2019 rotated-square. NIH Presented at: 2019 ACR/ARP Annual Meeting; November 8-13, 2019; Atlanta, GA. 10). Therapeutic approaches for psoriatic arthritis (PsA) include non-pharmacologic therapies, symptomatic treatments, tumor necrosis factor inhibitors, interleukin inhibitors, cytotoxic T lymphocyte antigen 4 â¦ Arthritis Rheumatol 2019; 71 Arthritis Rheumatol 2019; 71 (suppl 10) ACR/ARP 2019; Atlanta, Georgia, USA: 8â13 November. Serious AEs were similar across treatment arms. 10). Introduction. Arthritis Rheumatol. Arthritis Rheumatol . JAK inhibitors rotated-square. Abstract: Kulig P, et al. For a searchable version of these abstracts, please visit www.acrabstracts.org. Front Immunol. Related topics. Ann Rheum Dis 2017;76:978–91. Epub 2019 Aug 21. 2019;71(suppl 10), Abstract 1817; and Foley C et al. 13. 2018;70(suppl 10). Kremer J, Dougados M, Genovese MC, Emery P, Yang L, de Bono S, et al. Arthritis Rheumatol. Therapeutic Advances in Musculoskeletal Disease 2019 10.1177/1759720X19864492 Download Citation If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. At week 16, significantly higher proportions of IXEQ2W patients (n = 30 [30.6%]; P = 0.003) or IXEQ4W patients (n = 29 [25.4%]; P = 0.017) had achieved an ASAS40 response versus the placebo group (n = 13 [12.5%]), with statistically significant differences reported as early as week 1 with ixekizumab treatment. 10.1136/lupus-2019-lsm.199 Background Baricitinib (Bari), an oral selective inhibitor of Janus kinase (JAK)1 and JAK2, has been approved for the treatment of rheumatoid arthritis (RA) in over 50 countries including the United States, European countries, and Japan. ACR/ARP 2019 rotated-square. If you do not receive an email within 10 minutes, your email address may not be registered, and you may need to create a new Wiley Online Library account. Cardiovascular disease rotated-square. Epub 2015 Sep 24. 2015 Jul;14(7):622-32. doi: 10.1016/j.autrev.2015.03.003. Overall TEAEs for UPA and Active Comparators (E/100 â¦ Marzo-Ortega H, Mease PJ, Rahman P, Navarro-Compán V, Strand V, Dougados M, Combe B, Wei JC, Baraliakos X, Hunter T, Sandoval D, Li X, Zhu B, Bessette L, Deodhar A. Rheumatol Ther. van der Heijde D., Arthritis Rheumatol 2019; 71(Suppl 10), abs 0937 Ankylosing Spondylitis A Multicenter, Open-Label Extension Study to Evaluate the Long Term Safety and Efficacy of Bimekizumab in Subjects With Ankylosing Spondylitis Entheses – emerging concepts. USA.gov. Schwartzman S, Deodhar A, Kronbergs A, et al. Arthritis Rheumatol. 2019; 71 (suppl 10). Pages: 1-5420. Received: 30 July 2019; Accepted: 17 September 2019; Published: 04 October 2019. 2019;71(suppl 10â¦ Evaluating Inflammatory Versus Mechanical Back Pain in Individuals with Psoriatic Arthritis: A Review of the Literature. Mallinckrodt ARD LLC. Rheumatology (Oxford). Methotrexate rotated-square. As a key manifestation, it has been included in the Classification Criteria for Psoriatic Arthritis (CASPAR) and as a treatment domain for the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment guidelines . National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. A recent systematic review found the studies to be of high heterogeneity, small in numbers, and yielding inconsistent results. See this image and copyright information in PMC. Genovese M, Smolen J, Takeuchi T, et al. Guselkumab rotated-square. Epub 2018 Oct 22. © 2018 The Authors. Epub 2019 Dec 5. Request Username Can't sign in? Genovese M, Smolen J, Takeuchi T, et al. Li LY, Lu N, Lacaille D, Xie H, Esdaile J, Avina-Zubieta JA. Schwartzman S, Deodhar A, Kronbergs A, et al. Inflammatory bowel disease and anterior uveitis in patients treated with ixekizumab for radiographic axial spondyloarthritis: results from two phase 3 studies through 52 weeks. [PMC free article] [Google Scholar] N Engl J Med. 6. Robinson PC, Sengupta R, Siebert S. Non-radiographic axial spondyloarthritis (nr-axSpA): advances in classification, imaging and therapy. 2019;71(suppl 10): Abstract 930. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error, Collaborators, Please enable it to take advantage of the complete set of features! 2019;71(suppl 10). Therapeutic approaches for psoriatic arthritis (PsA) include non-pharmacologic therapies, symptomatic treatments, tumor necrosis factor inhibitors, interleukin inhibitors, cytotoxic T lymphocyte antigen 4 immunoglobulin, and Janus kinase inhibitors. 2016 ACR/ARHP Annual Meeting Abstract Supplement. Deodhar A, van der Heijde D, Gensler LS, Kim TH, Maksymowych WP, Østergaard M, Poddubnyy D, Marzo-Ortega H, Bessette L, Tomita T, Leung A, Hojnik M, Gallo G, Li X, Adams D, Carlier H, Sieper J; COAST-X Study Group. | 114), 16–23. 2019;71(suppl 10):abstract 2707. Statistically significant improvements in disease activity, function, quality of life, and spinal magnetic resonance imaging-evident inflammation were observed after 16 weeks of ixekizumab treatment versus placebo. Benedetti D, et al. Google Scholar Alfaleh MA, Alsaab HO, Mahmoud AB, Alkayyal AA, Jones ML, Mahler SM, Hashem AM. Arthritis Rheumatol 2016;68:282–98. 2015 ACR/ARHP Annual Meeting Abstract Supplement. Arthritis Rheumatol. Kroon FP, van der Burg LR, Ramiro S, Landewé RB, Buchbinder R, Falzon L, van der Heijde D. Cochrane Database Syst Rev. 2019;71(suppl 10â¦ BJU Int. 2019 Nov;71(11):1788-1800. doi: 10.1002/art.41032. [3]Langley RG, et al. 2020 Aug 21;22(1):195. doi: 10.1186/s13075-020-02288-8. Arthritis Rheumatol. Ruperto N, Brunner H, Cornejo GV, Berman A, Anton J, Cuttica R et al. Safety profile of baricitinib for the treatment of rheumatoid arthritis up to 7 years: an updated integrated safety analysis. Arthritis Rheumatol. Cedola F, Coras R, Fernandez-Bustamante M, et al. A randomized, double-blind, placebo-controlled, sixteen-week study of subcutaneous golimumab in patients with active nonradiographic axial spondyloarthritis. -, Braun J, Sieper J. Ankylosing spondylitis. 2015;67(Suppl 10):abstract 1050. Format. doi: 10.1007/s00296-017-3698-1.. Baker NA, Barbour KE, Helmick CG, Zack MM, Al snih S. Associations between arthritis and change in physical function in U.S. retirees. 2017 ACR/ARHP Annual Meeting Abstract Supplement. The modified Rodnan skin score (mRSS) is a widely used tool for the assessment of the extent and degree of skin â¦ van der Heijde D, Cheng-Chung Wei J, Dougados M, Mease P, Deodhar A, Maksymowych WP, Van den Bosch F, Sieper J, Tomita T, Landewé R, Zhao F, Krishnan E, Adams DH, Pangallo B, Carlier H; COAST-V study group. Arthritis Rheumatol. [4]Fleischmann, et al . Epub 2020 Aug 19. [5]van Vollenhoven, et al . We evaluated GUS efficacy and safety in a Phase 3, double-blind, PBO-controlled trial in â¦ Arthritis Rheumatol. 2019;71(suppl 10â¦ Upadacitinib rotated-square. Arthritis Rheumatol. ACR/ARP 2019 rotated-square. Lancet. -, Van der Heijde D, Ramiro S, Landewe R, Baraliakos X, van den Bosch F, Sepriano A, et al. Manica SR, Sepriano A, Pimentel-Santos F, Gouveia N, Barcelos A, Branco JC, Bernardes M, Ferreira RM, Vieira-Sousa E, Barreira S, Vinagre F, Roque R, Santos H, Madeira N, Rovisco J, Daniel A, Ramiro S. Arthritis Res Ther. 2015 Oct;67(10):2702-12. doi: 10.1002/art.39257. | 37. Baker NA, Barbour KE, Helmick CG, Zack MM, Al snih S. Arthritis and cognitive impairment in older adults. Abstract 1482. Lancet. 3 Data on File, Mallinckrodt, 2019. | Background/Purpose: Guselkumab (GUS), an anti-interleukin-23p19 monoclonal antibody, is approved to treat PsO. doi: 10.1002/14651858.CD010952.pub2. ClinicalTrials.gov NCT02696798. Mulder M, van den Reek J, de Jong E, et al. Morand E, et al. Rheumatol Ther. 2019;71(suppl 10). 2016 update of the ASAS‐EULAR management recommendations for axial spondyloarthritis. Volume 71, Issue S10. Patients (pts) are classified as nr-axSpA due to â¦ Treatment-emergent adverse events (AEs) with ixekizumab treatment were more frequent than with placebo. 2019;71(suppl 10â¦ Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Rheumatology International. Contact Vectra SOURCES: Jones J et al. Arthritis Rheumatol. 2019; 71 (4):496–506. Ward MM, Deodhar A, Gensler LS, Dubreuil M, Yu D, Khan MA, Haroon N, Borenstein D, Wang R, Biehl A, Fang MA, Louie G, Majithia V, Ng B, Bigham R, Pianin M, Shah AA, Sullivan N, Turgunbaev M, Oristaglio J, Turner A, Maksymowych WP, Caplan L. Arthritis Care Res (Hoboken). Furie R, et al. Conclusion: Isenberg D, Furie R, Jones N, et al. 2019:1-13. A total of 316 patients were randomized to receive placebo (n = 104), IXEQ2W (n = 98), or IXEQ4W (n = 114). J Rheumatol 1996;23:1866-71. Export Citation(s) Export Citations. 2018 Dec 8;392(10163):2441-2451. doi: 10.1016/S0140-6736(18)31946-9. Front. 2019;71(10):1599-1613. The purpose of … A fifty-two-week, randomized, placebo-controlled trial of certolizumab pegol in nonradiographic axial spondyloarthritis. 2015;386(9999):1137–46. 2020;72(suppl 10). Epub 2015 Mar 20. Arthritis Rheumatol. Of 2819 citations, we identified 10 articles [, , , , 12, , , , , ] which met predefined criteria, as summarized in Fig. [2]Baraliakos X, et al. Ann Rheum Dis. Reducing or Maintaining the Dose of Subcutaneous Tocilizumab in Patients With Rheumatoid Arthritis in Clinical Remission: A Randomized, OpenâLabel Trial Raimon Sanmarti MD, â¦ Phage Display Derived Monoclonal Antibodies: From Bench to Bedside. This site needs JavaScript to work properly. 2019;78(Suppl 2):891. Growth and development of patients with polyarticular-course juvenile idiopathic arthritis â¦ -, Ward MM, Deodhar A, Akl EA, Lui A, Ermann J, Gensler LS, et al. Arthritis Care Res (Hoboken) 2012;64:905–10. Tapering and withdrawal of tocilizumab in patients with systemic juvenile idiopathic arthritis in inactive disease: results from an alternative dosing regimen in the TENDER study. Venous thromboembolism rotated-square. Arthritis Rheumatol. 2019;71(suppl 10), Abstract 781 1 There is also insufficient guidance on BMD testing in patients with PsA as per recent major clinical practice guidelines. Clin Rheumatol 2017;36:2667-71. Allanore Y, Denton C, Khanna D, Soubrane C, Esperet C, Marrache F, et al. Clinical and biological changes in rheumatoid arthritis patients exposed to an anti-inflammatory diet [abstract]. In December 2018, Idorsia initiated a multiple-dose, efficacy and safety study with cenerimod for the treatment of adult patients with moderately to severely active, â¦ Cimzia ® (certolizumab pegol) approved by FDA for treatment of adults with active ankylosing spondylitis [press release]. 2018, 36 (Suppl. Arthritis Rheumatol. Background/Purpose: Non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) are considered part of the spectrum of axSpA. Plain Text. Arthritis Rheumatol 2018;70(Suppl 10). -. Response to baricitinib at 4 weeks predicts response at 12 and 24 weeks in patients with rheumatoid arthritis: results from two phase 3 studies. ] arthritis Rheumatol 2019 ; Accepted: 17 September 2019 ; 71 ( suppl ). Advances in classification, imaging and therapy guidance on BMD testing in patients with rheumatoid arthritis Association of Research... [ Google Scholar ] arthritis Rheumatol Rheumatol 2019 ; 71 ( 10 ): Abstract 930 ( PsA ) bone! 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